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Sperm antibodies are antibodies against sperm formed by the immune system. They can occur with the woman, as well as with the man. Increasingly, sperm antibodies are a potential cause of infertility.
When the woman's immune system produces antibodies to the man's sperm, the man's sperm are neutralized before they can fertilize the egg.
One disputed cause is the ingestion of the pill and the associated unprotected intercourse, which results in the woman having frequent contact with the semen. The sperm is then recognized as a foreign protein by the immune system.
Sperm antibodies can be detected via a blood test or in cervical mucus. Also important here is the assessment of the postcoital test.
But sperm antibodies were also increasingly observed in the man himself. This leads to an absurd reaction of the immune system in that it forms antibodies against the own sperm and thus blocks their activity. This causes the sperm in their mobility and vitality are restricted or completely blocked. This can be proven in the ejaculate by the so-called MAR test.
If sperm antibodies occur in men, this must be treated in the same way as a basic allergic reaction and can be very well neutralized with antisense treatment.
If sperm antibodies occur in the woman against the sperm of the man, a special antibody neutralization of the woman against certain immune cells of the man is necessary. So a normal and natural fertilization is possible again.
The treatment according to this immunological principle is also indicated in women who suffer from unclear rheumatoid inflammatory complaints, as very often sperm antibodies trigger inflammatory complexes, repeatedly activated by sexual intercourse and re-contact with the sperm. Again, autoantibody desensitization and immunotherapies are very successful.