TOP Doctors for Sperm Antibodies

Sperm antibodies are antibodies against sperm formed by the immune system. They can occur with the woman, as well as with the man. Increasingly, sperm antibodies are a potential cause of infertility.

When the woman's immune system produces antibodies to the man's sperm, the man's sperm are neutralized before they can fertilize the egg.

One disputed cause is the ingestion of the pill and the associated unprotected intercourse, which results in the woman having frequent contact with the semen. The sperm is then recognized as a foreign protein by the immune system.

Sperm antibodies can be detected via a blood test or in cervical mucus. Also important here is the assessment of the postcoital test.

But sperm antibodies were also increasingly observed in the man himself. This leads to an absurd reaction of the immune system in that it forms antibodies against the own sperm and thus blocks their activity. This causes the sperm in their mobility and vitality are restricted or completely blocked. This can be proven in the ejaculate by the so-called MAR test.

If sperm antibodies occur in men, this must be treated in the same way as a basic allergic reaction and can be very well neutralized with antisense treatment.

If sperm antibodies occur in the woman against the sperm of the man, a special antibody neutralization of the woman against certain immune cells of the man is necessary. So a normal and natural fertilization is possible again.

The treatment according to this immunological principle is also indicated in women who suffer from unclear rheumatoid inflammatory complaints, as very often sperm antibodies trigger inflammatory complexes, repeatedly activated by sexual intercourse and re-contact with the sperm. Again, autoantibody desensitization and immunotherapies are very successful.

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Latest News in Sperm Antibodies

What exactly are anti-sperm antibodies?


Anti-sperm antibodies can occur in both men and women. Antibodies are protein molecules. They bind to a certain place on the sperm. Once tied, they can interfere with sperm abilities in various ways. They may immobilize the sperm, cause multiple sperm to clump together, reduce their ability to pass through the cervical mucus, or prevent them from binding to the oocyte and penetrating the cell membrane. Anti-sperm antibodies are commonly found in men after vasectomy, after testicular injury and after infection. The cause of anti-sperm antibodies in the woman is unknown.

Researchers classify antibodies by type (IgA, IgG and IgM). Continue to the place (head, center or tail) on the sperm to which they connect. Studies show that the IgG antibodies are more common in males and that the IgA type is found in the mucus and follicular fluid in women. The significance of these findings is still unclear. Bonding to the sperm head interferes with attachment and penetration of the ovum, while binding to the tail impairs motility.

The investigation of the type of antibody or the binding site can unfortunately make no statement about the conception probability. Attempts to treat this condition - such as lowering antibody levels with steroids or removing antibodies from the sperm - have shown that the benefit is limited and causes other complications. Ovulation induction followed by fertilization with ICSI (a process in which the sperm cell is transferred directly into an ovum) appears to be the best treatment for such cases.

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