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Vagotomy is the surgical transection of branches of the vagus nerve, which supply the secreting cells of the stomach or duodenum. The operation is mainly used in patients with gastric and duodenal ulcers because such ulcers are due to excessively acid secretion. Meanwhile, conservative drug solutions have largely replaced vagotomy.
For the treatment of patients with gastric or duodenal ulcers are now the so-called proton pump inhibitors available, which still surpass the operation in terms of effectiveness. Before the advent of these modern therapies, vagotomy played an important role in patients with gastric or duodenal ulcer, especially in the form of selective proximal vagotomy.